High Court Invalidates Shionogi EPC Patent to HIV Drug “Tivicay” Today in Merck Sharp and Dohme

Evangelos Giannitsis 2* Aqp4-igg Immunoprecipitation Assay Optimization

Employment or Leadership: None declared. Consultant or Advisory Role: None declared. Stock Ownership: None declared. Honoraria: E. Giannitsis, Merck Sharp & Dohme, Lilly, Bristol Myers Squibb, GlaxoSmithKline, Roche Diagnostics, and Bayer; H.J. Roth, Merck Sharp & Dohme and Roche Diagnostics. Research Funding: E. Giannitsis received funds and access to assays from Roche Diagnostics. Expert Test...

Federal court invalidates Sanofi's Plavix patent for alleged insufficiency and obviousness.

On December 6, 2011, the Federal Court of Canada issued its decision1 in the well-known dispute between Apotex Inc. and Sanofi-Aventis over the anticoagulant drug, clopidogrel bisulfate, sold in Canada under the brand name Plavix. This compound is a single enantiomer of a previously disclosed racemate. The Court invalidated Sanofi’s patent (Canadian patent no. 1,366,777, “the ′777 Patent”). An ...

Public Assessment Report Paediatric data COSOPT eye drops solution Dorzolamide Hydrochloride Timolol Maleate Marketing Autorisation Holder: Merck Sharp & Dohme

Modeling and Simulation at the Interface of Nonclinical and Early Clinical Drug Development

1Global DMPK, Innovative Medicines, AstraZeneca R&D, Södertälje, Sweden; 2Current affiliation: Merck Research Laboratories, Merck & Co., Inc., Upper Gwynedd, PA, USA; 3European Medicines Agency, London, UK; 4Division of Pharmacology, Leiden Academic Center for Drug Research, Leiden University, Leiden, The Netherlands; 5M&S, Merck Sharp & Dohme, Oss, The Netherlands. Correspondence: SAG Visser (...

Drug Discovery Tools and the Clinical Research Exemption from Patent Infringement

Authors’ Note: Since we wrote the following article, the Court of Appeals for the Federal Circuit handed down its decision in Integra LifeSciences I, Ltd. v. Merck KGAA, Nos. 02-1052 and 02-1065) (Fed. Cir. June 6, 2003). The Court affirmed the holding of the District Court for the Southern District of California that the clinical research exemption from patent infringement, codified in 35 USC ...